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Oncology - Tissue biopsy
PNAClamp™ Mutation Detection Kit IDH1
Mutations of IDH1 (isocitrate dehydrogenase 1,IDH1) can be found in glioblastoma and myeloproliferative neoplasm. Detection of IDH1mutations can be a positive predictor of a prognosis and a molecular marker for glioblastoma patients. On the other hand, it is reported that IDH1 mutations correlate with poor prognosis in myeloproliferative neoplasm.
PNAClamp™ IDH1 Mutation Detection Kit is a new member of somatic mutation detection kits utilizing PNA-mediated PCR Clamping technology, and can help patients choose the right medicine and monitor prognosis.
PNAClamp™ IDH1 Mutation Detection Kit is a new member of somatic mutation detection kits utilizing PNA-mediated PCR Clamping technology, and can help patients choose the right medicine and monitor prognosis.
CAT NO.
PNAC-5001
DETAILS
Total 5 IDH1 mutations can be detected.
Mutations | Size |
Codon 132 | 25 tests |
5 |
FEATURES
- 01High sensitivity and specificity even with small amount of DNA (1% LOD with 10 ng wild/mutant type mixed DNA)
- 02Real-Time PCR based ready-to-use kit
- 03Short running time (within 3 hours)
PROCEDURE
sample preparation
Extraction of Total DNA 
Amplification of target DNA by Real-Time PCR 
Analysis of Result
COMPATIBLE SAMPE TYPE
- FFPE tissue
- Fresh tissue
- Fresh tissue
COMPATIBLE Real-Time PCR machine
CFX96
(Bio-Rad)
LightCycler 480II
(Roche)
ABI7500
(Thermo Fisher Scientific)
Rotor-Gene Q
(Qiagen)
