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Oncology - Tissue biopsy

PNAClamp™ Mutation Detection Kit BCR-ABL

CML (Chronic myelogenous leukemia) patients who has consistently treated with Imatinib (Gleevec), have acquired point mutations in tyrosine kinase domain of BCR-ABL fusion gene. Especially, T315I mutation is known as a mutation associated with Imatinibresistance and observed with high frequency.
It is important to monitor patients treated with Imatinibby BCR-ABLfusion gene mutation test to prevent therapy failure due to drug resistance by mutation.
CAT NO.
PNAC-7001

DETAILS


 

BCR-ABL T315I can be detected by PNAClamp™ BCR-ABL Mutation Detection Kit.

 

 Mutations

Size 

 Exon 6

25 tests 

T315I (944C)


FEATURES

  • 01High sensitivity and specificity even with small amount of DNA(1% LOD with 10 ng wild/mutant type mixed DNA)
  • 02Real-Time PCR based ready-to-use kit
  • 03Short running time (within 3 hours)

PROCEDURE

  • sample preparation
  • Extraction of Total DNA
  • Amplification of target DNA by Real-Time PCR
  • Analysis of Result

COMPATIBLE SAMPE TYPE

- Whole Blood

COMPATIBLE Real-Time PCR machine

  • CFX96
(Bio-Rad)
의 이미지

    CFX96
    (Bio-Rad)

  • LightCycler 480II
(Roche)
의 이미지

    LightCycler 480II
    (Roche)

  • ABI7500
(Thermo Fisher Scientific)
의 이미지

    ABI7500
    (Thermo Fisher Scientific)

  • ABI7900HT
(Thermo Fisher Scientific)
의 이미지

    ABI7900HT
    (Thermo Fisher Scientific)

  • StepOnePlus
(Thermo Fisher Scientific)
의 이미지

    StepOnePlus
    (Thermo Fisher Scientific)

  • QuantStudio 5
(Thermo Fisher Scientific)
의 이미지

    QuantStudio 5
    (Thermo Fisher Scientific)

  • Rotor-Gene Q
(Qiagen)
의 이미지

    Rotor-Gene Q
    (Qiagen)

‘*’ marked information should be submitted.